|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells.
|
31747859 |
2020 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study indicated that the XRCC1 rs25487 was a risk factor for the susceptibility of HCC, which was verified by the TSA.
|
31478224 |
2020 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the rs25489 and rs1799782 polymorphisms were associated with increased risk of HCC.
|
31478224 |
2020 |
|
rs1799782
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In addition, the rs25489 and rs1799782 polymorphisms were associated with increased risk of HCC.
|
31478224 |
2020 |
|
rs9679162
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A GALNT14 rs9679162 genotype-guided therapeutic strategy for advanced hepatocellular carcinoma: systemic or hepatic arterial infusion chemotherapy.
|
31611591 |
2020 |
|
rs1695
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Herein, we investigated the relationship of three GSTs polymorphisms (GSTT1 deletion, GSTM1 deletion, GSTP1 rs1695) as well as GSTP1 promoter region DNA methylation and HCC risk with a particular focus on the interaction with OCPs exposure among 90 HCC cases and 99 controls in a Chinese population.
|
31731000 |
2020 |
|
rs72613567
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We tested the association of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical liver disease and mortality in 111,612 individuals from the Danish general population, including 497 with cirrhosis and 113 with hepatocellular carcinoma.
|
31155741 |
2020 |
|
rs6025211
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we aimed to investigate whether combination of three previously identified single nucleotide polymorphism (SNP) predictors (GALNT14-rs9679162, WWOX-rs13338697, and rs6025211) could guide our choice between systemic chemotherapy, HAIC, and targeted agents in aHCC patients.
|
31611591 |
2020 |
|
rs7975232
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Apa1 (rs7975232) SNP in the vitamin D receptor is linked to hepatocellular carcinoma in hepatitis C virus cirrhosis.
|
31682785 |
2020 |
|
rs920778
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma.
|
31759985 |
2020 |
|
rs2844512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2844512 G > C variant in LINC01149 was identified to facilitate HBV spontaneous recovery (OR = 0.84, 95% CI = 0.77-0.92) but increase the risk of HCC (OR = 1.21, 95% CI = 1.11-1.32) in combined samples.
|
31754211 |
2020 |
|
rs34000982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that the rs34000982 polymorphism may contribute to HCC susceptibility, in full or at least partially through the effect on HMGB1 transcriptional activity by disturbing the binding of miR-636 with the 3'UTR of HMGB1.
|
31777261 |
2020 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.
|
30947687 |
2019 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC.
|
31419949 |
2019 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nevertheless, we also detected significant associations between rs259</span>6542G>A and HCV-induced HCC</span>.
|
30967497 |
2019 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC.
|
30882647 |
2019 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
|
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The present study also indicates that <i>STAT4</i> rs7574865 polymorphism increased the risk of chronic HBV infection and HCC.
|
31160486 |
2019 |
|
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In contrast, STAT4-rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk.
|
30289982 |
2019 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This review will discuss these findings as well as their clinical significance and implications for the development of a strategy to target multiple molecules as a therapy for p53-R249S-harboring HCC.
|
30608603 |
2019 |
|
rs1012068
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
|
rs1012068
|
|
|
0.760 |
GeneticVariation |
BEFREE |
After controlling for the influence of sex, smoking and drinking, this study showed a significant relationship between the polymorphism of DEPDC5 rs1012068 and HBV-related HCC.
|
30683632 |
2019 |
|
rs1012068
|
|
|
0.760 |
GeneticVariation |
BEFREE |
There was a significant correlation between DEPDC5 rs1012068A/C and HBV-related HCC in the Han Chinese population.
|
30683632 |
2019 |